Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 102 222.41 61.24 30,664,046
Mutual Fund 28 35.54 7.73 3,871,785
Insider 3 0.32 0.07 34,628

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 67 125.06 36.10 18,075,755
Sellers 29 -76.04 12.16 -6,089,820
Net -- 49.01 23.94 11,985,935

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 222.41 61.24 30,664,046
Top 10 Inst. 169.79 40.47 20,263,387
Top 20 Inst. 198.69 52.59 26,333,141
Top 50 Inst. 220.07 60.26 30,170,600

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 10 2.38 0.96 479,653
Aggressive Growth 2 1.37 0.55 276,793
Core Growth 5 0.98 0.40 198,088
Growth 3 0.03 0.01 4,772
Income 2 0.32 0.13 64,041
Income Value 1 0.20 0.08 40,541
Yield 1 0.12 0.05 23,500
Index 7 9.04 3.63 1,815,921
Other 43 135.22 37.20 18,626,548
Broker Dealer 10 1.93 0.78 390,050
GARP 9 23.45 9.01 4,511,326
Hedge Fund 20 92.29 19.78 9,904,349
VC/Private Equi 4 17.55 7.63 3,820,823
Value 11 13.17 5.36 2,682,565
Core Value 6 12.82 5.22 2,615,591
Deep Value 5 0.35 0.13 66,974

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Deerfield Management Company, L.P. 2,773,861 5.54 2,455,861 6/1/18
Frontier Capital Management Company, LLC 2,720,937 5.43 2,248,382 3/31/18
DexCom Inc 2,500,000 4.99 2,500,000 2/13/18
TPG Capital, L.P. 2,496,194 4.99 -- 3/31/18
Federated Global Investment Management Corp. 2,250,000 4.49 2,250,000 3/31/18
First Light Asset Management, LLC 2,146,963 4.29 -2,587,275 6/6/18
Corrib Capital Management L.P. 1,411,836 2.82 -3,088,164 4/30/18
The Vanguard Group, Inc. 1,380,742 2.76 1,274,255 3/31/18
Acuta Capital Partners, LLC 1,346,360 2.69 1,346,360 3/31/18
Blickenstaff (Kim D) 1,236,494 2.47 750,000 2/13/18
Schonfeld Strategic Advisors LLC 1,000,000 2.00 1,000,000 3/31/18
Wasatch Advisors, Inc. 905,977 1.81 627,410 3/31/18
Millennium Management LLC 851,786 1.70 851,786 3/31/18
venBio Select Advisor LLC 783,910 1.57 783,910 3/31/18
Armistice Capital LLC 531,354 1.06 531,354 10/13/17
Millrace Asset Group, Inc. 500,000 1.00 500,000 3/31/18
Medical Strategy GmbH 402,707 0.80 283,339 4/30/18
Weiss Multi-Strategy Advisers LLC 400,000 0.80 400,000 3/31/18
Delphi Ventures L.P. 366,803 0.73 1 12/31/17
DZ Bank AG Deutsche Zentral-Genossenschaftsbank 327,217 0.65 327,217 3/31/18
Balyasny Asset Management LP 287,500 0.57 287,500 3/31/18
Eventide Asset Management, LLC 275,000 0.55 275,000 3/31/18
Chartwell Investment Partners, LLC 257,726 0.51 257,726 3/31/18
Essex Investment Management Company, LLC 256,793 0.51 256,793 3/31/18
Geode Capital Management, L.L.C. 254,651 0.51 237,655 3/31/18
Cavanaugh (Kevin M) 239,100 0.48 239,100 4/30/18
Kennedy Capital Management, Inc. 199,875 0.40 199,875 3/31/18
HLM Venture Partners 173,916 0.35 1 12/31/17
BlueCrest Capital Management LLP 173,282 0.35 173,282 3/31/18
Renaissance Technologies LLC 157,227 0.31 130,377 3/31/18
Marshall Wace LLP 150,525 0.30 150,409 3/31/18
Arens (Mathew P) 133,000 0.27 8,000 6/6/18
Apo Asset Management GmbH 121,000 0.24 -- 4/30/18
J.P. Morgan Securities LLC 119,472 0.24 119,472 3/31/18
Spark Investment Management LLC 114,300 0.23 114,300 3/31/18
KeyBanc Capital Markets 112,653 0.23 91,300 3/31/18
Tibra Equities Europe, Ltd. 86,447 0.17 86,447 3/31/18
Northern Trust Investments, Inc. 83,747 0.17 83,747 3/31/18
Westfield Capital Management Company, L.P. 76,300 0.15 76,300 3/31/18
Deutsche Asset Management Americas 71,512 0.14 71,404 3/31/18
Wellington Management Company, LLP 64,076 0.13 50,076 2/28/18
Dafna Capital Management, LLC 60,000 0.12 60,000 3/31/18
Deutsche Bank Securities Inc. 55,382 0.11 55,382 3/31/18
Jacobs Levy Equity Management, Inc. 52,350 0.10 -26,536 3/31/18
RBC Capital Markets Wealth Management 47,500 0.09 47,500 3/31/18
Barclays Bank PLC 47,100 0.09 20,300 3/31/18
First Mercantile Trust Company 44,866 0.09 40,969 3/31/18
BlackRock Institutional Trust Company, N.A. 41,720 0.08 125 3/31/18
BNY Mellon Asset Management 40,541 0.08 40,541 3/31/18
Squarepoint Capital LLP 39,898 0.08 39,898 3/31/18

* Insider values reflect direct beneficial ownership.

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