Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 142 548.80 71.39 40,475,582
Mutual Fund 108 268.70 22.65 12,838,739
Insider 4 0.37 0.06 36,382

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 103 305.17 39.01 22,118,331
Sellers 27 -98.85 11.84 -6,712,136
Net -- 206.33 27.17 15,406,195

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 548.80 71.39 40,475,582
Top 10 Inst. 392.23 40.23 22,810,128
Top 20 Inst. 447.72 57.08 32,361,165
Top 50 Inst. 519.50 67.42 38,225,289

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 19 99.49 8.18 4,636,758
Aggressive Growth 3 47.86 3.83 2,173,421
Core Growth 11 15.26 1.43 811,332
Growth 5 36.38 2.91 1,652,005
Income 2 2.66 0.24 138,874
Income Value 1 2.54 0.20 115,374
Yield 1 0.12 0.04 23,500
Index 16 75.32 8.43 4,778,671
Other 55 224.45 35.32 20,021,892
Broker Dealer 12 2.68 0.54 308,606
GARP 13 86.64 7.79 4,414,763
Hedge Fund 25 109.61 18.35 10,404,345
Specialty 1 1.62 0.13 73,355
VC/Private Equi 4 23.91 8.50 4,820,823
Value 15 68.20 6.11 3,463,512
Core Value 9 63.91 5.71 3,237,800
Deep Value 6 4.29 0.40 225,712

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Deerfield Management Company, L.P. 2,773,861 4.89 2,455,861 6/1/18
BlackRock Institutional Trust Company, N.A. 2,713,060 4.79 2,671,340 6/30/18
Federated Global Investment Management Corp. 2,656,500 4.69 406,500 6/30/18
Frontier Capital Management Company, LLC 2,633,456 4.64 -87,481 6/30/18
DexCom Inc 2,500,000 4.41 2,500,000 2/13/18
TPG Capital, L.P. 2,496,194 4.40 -- 3/31/18
First Light Asset Management, LLC 2,146,963 3.79 -2,587,275 6/6/18
Fred Alger Management, Inc. 1,970,184 3.48 1,950,184 6/30/18
Emerald Advisers, Inc. 1,508,074 2.66 1,507,459 6/30/18
Corrib Capital Management L.P. 1,411,836 2.49 -3,088,164 4/30/18
The Vanguard Group, Inc. 1,380,742 2.44 1,274,255 3/31/18
Delphi Ventures L.P. 1,366,803 2.41 1,000,000 3/31/18
Acuta Capital Partners, LLC 1,346,360 2.37 1,346,360 3/31/18
Blickenstaff (Kim D) 1,236,494 2.18 750,000 3/31/18
Schonfeld Strategic Advisors LLC 1,000,000 1.76 1,000,000 3/31/18
Millennium Management LLC 851,786 1.50 851,786 3/31/18
venBio Select Advisor LLC 783,910 1.38 783,910 3/31/18
Wasatch Advisors, Inc. 553,588 0.98 -352,389 6/30/18
Armistice Capital LLC 531,354 0.94 531,354 10/13/17
Millrace Asset Group, Inc. 500,000 0.88 500,000 3/31/18
Medical Strategy GmbH 482,707 0.85 80,000 4/30/18
Weiss Multi-Strategy Advisers LLC 400,000 0.71 400,000 3/31/18
DZ Bank AG Deutsche Zentral-Genossenschaftsbank 327,217 0.58 327,217 3/31/18
Cortina Asset Management L.L.C. 311,560 0.55 311,560 6/30/18
Columbia Wanger Asset Management, LLC 307,902 0.54 307,902 6/30/18
Balyasny Asset Management LP 287,500 0.51 287,500 3/31/18
Eventide Asset Management, LLC 275,000 0.49 275,000 3/31/18
Geode Capital Management, L.L.C. 254,651 0.45 237,655 3/31/18
Cavanaugh (Kevin M) 239,100 0.42 239,100 4/30/18
EAM Investors, LLC 200,187 0.35 200,187 6/30/18
Kennedy Capital Management, Inc. 199,875 0.35 199,875 3/31/18
Citadel LLC 184,764 0.33 184,764 6/30/18
HLM Venture Partners 173,916 0.31 -- 3/31/18
BlueCrest Capital Management LLP 173,282 0.31 173,282 3/31/18
Renaissance Technologies LLC 157,227 0.28 130,377 3/31/18
Balter Capital Management, LLC 156,084 0.28 156,084 4/30/18
Chartwell Investment Partners, LLC 153,736 0.27 -103,990 6/30/18
Marshall Wace LLP 150,525 0.27 150,409 3/31/18
BlackRock Investment Management, LLC 149,278 0.26 149,278 6/30/18
Essex Investment Management Company, LLC 145,165 0.26 -111,628 6/30/18
Arens (Mathew P) 133,000 0.23 8,000 6/6/18
Spark Investment Management LLC 122,300 0.22 8,000 6/30/18
Apo Asset Management GmbH 121,000 0.21 -- 6/30/18
J.P. Morgan Securities LLC 119,472 0.21 119,472 3/31/18
BNY Mellon Asset Management 115,374 0.20 74,833 6/30/18
Bellevue Asset Management AG 114,006 0.20 114,006 6/30/18
Principal Funds, Inc. 112,088 0.20 112,088 6/30/18
Allen (Dick P) 102,761 0.18 85,539 3/31/18
Engineers Gate Manager, L.P. 98,761 0.17 98,761 6/30/18
Charles Schwab Investment Management, Inc. 95,686 0.17 95,686 6/30/18

* Insider values reflect direct beneficial ownership.

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